• Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease 

      Staubo, Sara C.; Fuskevåg, Ole Martin; Toft, Mathias; Lie, Ingeborg H.; Alvik, Kirsti Margrete Johansen; Jostad, Pål; Tingvoll, Stein H.; Lilleng, Hallvard; Rosqvist, Kristina; Størset, Elisabet; Odin, Per; Dietrichs, Espen; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-13)
      Background and purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD.<p> <p>Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire ...
    • Pro-arrhythmic effect of escitalopram and citalopram at serum concentrations commonly observed in older patients – a study based on a cohort of 19,742 patients 

      Faraj, Pari; Størset, Elisabet; Hole, Kristine; Smith, Godfrey L; Molden, Espen; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-26)
      Background - For a decade, patients have been advised against using high citalopram- and escitalopram-doses due to risk for ventricular arrhythmia and cardiac arrest. Still, these drugs are widely used to treat depression and anxiety especially in older patients. It is unclear why they are cardiotoxic and at what serum concentrations patients are at risk for arrhythmias. Thus, how many patients that ...